{"id":18380,"date":"2025-06-03T19:39:56","date_gmt":"2025-06-03T19:39:56","guid":{"rendered":"https:\/\/www.watanserb.com\/en\/?p=18380"},"modified":"2025-06-03T19:39:56","modified_gmt":"2025-06-03T19:39:56","slug":"breakthrough-car-t-therapy-shows-remarkable-results-against-advanced-stomach-cancer","status":"publish","type":"post","link":"https:\/\/www.watanserb.com\/en\/2025\/06\/03\/breakthrough-car-t-therapy-shows-remarkable-results-against-advanced-stomach-cancer\/","title":{"rendered":"Breakthrough CAR-T Therapy Shows Remarkable Results Against Advanced Stomach Cancer"},"content":{"rendered":"

Watan<\/em><\/strong>-A groundbreaking and innovative treatment for some of the most difficult-to-treat stomach cancers has shown promising results in a Phase II clinical trial, significantly improving tumor shrinkage and survival rates, according to Science Alert.<\/p>\n

The therapy, a form of CAR-T cell immunotherapy, involves collecting a patient’s own immune cells, genetically modifying them to better target cancer cells, and then reinfusing them into the bloodstream.<\/p>\n

This specific treatment is called Satricabtagene Autoleucel, or Satri-cel, and it targets the CLDN18.2 protein, which certain tumors exploit to grow. Patients who received Satri-cel lived around 40% longer on average than those on traditional therapies.<\/p>\n

The trial, conducted by researchers across institutions in China, found that tumors treated with Satri-cel were more likely to shrink and took longer to progress compared to those treated with conventional cancer drugs.<\/p>\n

\"A
Cancer prevention tips<\/figcaption><\/figure>\n

The study involved 156 participants with advanced gastric or gastroesophageal junction cancer who had already failed at least two other treatment options\u2014patients with extremely limited alternatives.<\/p>\n

Dr. Lin Shen of the Beijing Cancer Hospital stated:”For heavily pre-treated patients with advanced gastric or gastroesophageal junction cancer and poor prognoses, Satri-cel demonstrated superior effectiveness, offering significant clinical benefits including improved progression-free survival, overall survival, and tumor response rates.”<\/p>\n

Key results include:<\/p>\n

    \n
  • \n

    Median overall survival: 7.92 months with Satri-cel vs. 5.49 months with standard care<\/p>\n<\/li>\n

  • \n

    Tumor shrinkage: observed in 22% of Satri-cel patients vs. 4% in the control group<\/p>\n<\/li>\n

  • \n

    Time to disease progression: 3.25 months with Satri-cel vs. 1.77 months without<\/p>\n<\/li>\n<\/ul>\n

    \"A
    cancer immunotherapy trial<\/figcaption><\/figure>\n

    These results are considered remarkable across multiple clinical benchmarks, reinforcing the therapy\u2019s potential in treating difficult cancers.<\/p>\n

    Dr. Shen concluded:”This introduces new hope for patients suffering from medically challenging and advanced-stage diseases.”<\/p>\n","protected":false},"excerpt":{"rendered":"

    Watan-A groundbreaking and innovative treatment for some of the most difficult-to-treat stomach cancers has shown promising results in a Phase II clinical trial, significantly improving tumor shrinkage and survival rates, according to Science Alert. The therapy, a form of CAR-T cell immunotherapy, involves collecting a patient’s own immune cells, genetically modifying them to better target …<\/p>\n","protected":false},"author":1,"featured_media":14805,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[2536,5812,5811,5813],"class_list":["post-18380","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lifestyle","tag-cancer","tag-car-t-therapy","tag-stomach-cancers","tag-the-cldn18-2-protein"],"yoast_head":"\nBreakthrough CAR-T Therapy Shows Remarkable Results Against Advanced Stomach Cancer - Watan<\/title>\n<meta name=\"description\" content=\"A new CAR-T cell therapy, Satri-cel, has demonstrated significant tumor shrinkage and extended survival in patients.. advanced stomach cancer\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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